Sunday, August 23, 2020

Project Execution free essay sample

During this stage the task administrator will arrange and guide venture assets to meet the goals of the undertaking plan. As the task unfurls, it is the venture manager’s occupation to coordinate and deal with every movement on the undertaking, at all times. That is occurs in the execution period of the task lifecycle; basically follow the arrangement, set up, and handle any issues that surface. The execution stage is the place the task group really accomplishes the venture work to create the expectations. The word deliverable methods anything anticipate conveys. The expectations for the venture incorporate the entirety of the items or administrations that the group is performing for the customer, client or support including all the undertaking the board reports that set up. The means did to construct every deliverable will change contingent upon the sort of venture that are embraced, and can't thusly be depicted here in any genuine detail. We will compose a custom exposition test on Venture Execution or then again any comparative point explicitly for you Don't WasteYour Time Recruit WRITER Just 13.90/page For example designing and broadcast communications ventures will concentrate on utilizing gear, assets and materials to make each extend deliverable, though PC programming undertakings may require the turn of events and execution of programming code practices to create each task eliverable. The exercises required to assemble every deliverable will be obviously recognized inside the task necessities record and undertaking plan as needs be. Task chief organizes the work, however he needs to accomplish more than negligible conveyance of the outcomes. He likewise needs to monitor how well the group performed. The executing stage keeps the undertaking plan on target with cautious checking and control procedures to guarantee the last deliverable meets the endorsement rules set by the client. This stage is commonly where affirmed changes are executed. Barron, 2009, Â ¶ 2). http://cnx. organization/content/m32189/most recent/Project Execution Level Plans The venture execution plan character izes how the undertaking group will configuration, build, introduce, commission, and start up the offices. The focal point of the undertaking execution plan is on the execution stage, after approval, when a large portion of the work is done and cash spent. The venture execution plan incorporates making the task level arrangement for: * Meeting the undertaking goals * Achieving HSE destinations * Managing change * Organizing and contracting for execution * Managing execution dangers Aligning the undertaking group for execution * Managing proprietor and contractual worker issue and interfaces * Quality administration plan * Cost, calendar, and asset the board plan for execution. Venture Execution follows the Project Planning Phase and preferably starts once the Project Plan has been endorsed and base lined. Venture Execution is described by the real work on the assignments arranged and venture Control includes the correlation of the real execution with the arranged presentation and ma king relevant restorative move to get the ideal yield. Task Team Responsibilities for Execution Phase Project Manager is liable for execution estimation which incorporates discovering changes among arranged and real work, cost and timetable. The undertaking director doles out the errands to the colleagues and they follow the necessary strategy. The undertaking director gives the status reports to all the imperative partners so as to give perceivability. The Stakeholders survey the measurements and change and start fundamental strides for the differences decided so as to finish the task inside financial plan and time. The essential procedures of the Project Execution and Control are the execution of the venture plan and surveying the measurements and delivering the status reports. The change control process characterizes the systems to deal with the progressions that are presented during the task execution and control stage. The encouraging procedures during Project Execution and Control can be: * Quality Assurance and Quality Control. * Performance Monitoring. * Information Distribution or Status Reporting. * Project Administration. * Risk Monitoring and Control. * Scope Control. * Schedule and Cost Control. Agreement Administration. Venture Execution and Control Phase has an immediate connection to extend progress and partners desires. On the off chance that the minor issues are not seen, they sway cost, calendar and hazard and see the venture from the Project Plan, therefore underscoring the significance for the Project Execution and Control Phase. (http://www. visitask. com/venture the board e xecution-stage. asp) Activities of task execution stage Implementation of following administration forms under venture execution will assist with overseeing time, cost, quality, change, dangers and issues.

Friday, August 21, 2020

Monty Python vs Church Debate free essay sample

Remark in transit speakers adjust their communicated in language to suit the circumstance. † Throughout the transcript, each side has a reasonable contention: Monty Python has the reason to guard the film while the Church has the reason to assault ‘Monty Python. ’ However, this as well as the motivation behind diversion being casted through the transcript. Right off the bat, shielding ‘Monty Python,’ is said by John Cleese and Michael Palin. â€Å"†¦Popper’s on about with the falsifiability of hypotheses. Here, John Cleese has adjusted a progressively genuine tone and the collection of Carl Popper, than before as he says something. Subsequently, it remarks on John Cleese’s scholarly capacity, which scares the resistance since they can't contend against an entrenched hypothesis. Moreover, in this transcript Michael Palin masks his arranged discourse by adjusting his language by utilizing fences and causing his discussion to have level sound with the goal that his focuses don’t appear to be so immediate and accusative, â€Å"I feel that, uh†¦sort of†¦we’ve accomplished for three arrangement, we’ve accomplished for three movies Here, it appears as though Michael Palin’s point is very trivial because of the supports, nonetheless, what he attempts to state is very incredulous of the resistance as he attempts to state that they don’t recognize what they are discussing. We will compose a custom exposition test on Monty Python versus Church Debate or then again any comparative point explicitly for you Don't WasteYour Time Recruit WRITER Just 13.90/page â€Å"I contemplate religion†¦Ã¢â‚¬  here, Michael Palin adjusts his communicated in language by deciding not to utilize Standard English; he utilizes constrictions and this has a similar impact as a fence since it relax his point, guaranteeing that nobody will think about it literally. It is likewise very amusing by preventing that not all from securing the film was about religion when really, the entire motivation behind the film was to criticize Jesus. The impact of utilizing incongruity is focalized in light of the fact that it gets the crowds consideration and attracts their enthusiasm to what Michael Palin says, yet additionally, by utilizing fences, it shows how they comprehend what their rival is stating and how they sabotage them. In actuality, the resistance who are assaulting ‘Monty Python,’ turn crazy as they misinterpret their focuses, â€Å"†¦dredge up this hopeless little film. Here, Malcolm Muggeridge adjusts his language from a proper tone and now he accepts it individual as he starts to legitimately affront Monty Python. We can comprehend this is a shortcoming of his as Malcolm’s feelings have shown signs of improvement of him. In addition, as the second 50% of the transcript advances, Malcolm again adjusts his language, with the goal that it is like John Cleese’s, as he attempts to accomplish listener support by getting giggling, â€Å"Well, at that point you more likely than not read cursorily at your school, that’s all,† Malcolm makes a useless point as he doesn't accomplish anything. â€Å"I identify with you† (crowd chuckling), here, Malcolm makes a kill remark so the crowd will giggle and not pay attention to John Cleese, in any case, this to a degree, throws Malcolm of being second rate compared to John Cleese in light of the fact that Malcolm feels as though he can't coordinate to the listener bolster that John Cleese has and accordingly, Malcolm feels that he needs to pick senseless kill remarks. In like manner, Mervyn Stockwood has additionally turned to draining out giggling by adjusting his language from Received Pronunciation, â€Å"But they might not have any desire to contrast it with Fawlty Towers! By adjusting his collection so he appears John Cleese, Mervyn Stockwood asks for a reaction from the crowd as he shouts and takes a gander at the crowd as though he is trusting that the crowd will begin giggling. As should be obvious, despite the fact that both Mervyn Stockwood and Malcolm Muggeridge adjust their communicated in language, it doesn't profit them on the grounds that because of it, they become very unique by offering remarks, which depicts how they have thought about Monty Python’s remarks literally. Moreover, in this discussion both Monty Python and the Church impact one another and the crowd by utilizing different artistic gadgets and by adjusting their communicated in language. â€Å"It’s likewise about shut frameworks of thought†¦Ã¢â‚¬  here, synchronous discourse is available as John Cleese takes over from Michael Palin before another person does. Not at all like Michael Palin, John Cleese doesn't support and makes a progressively self-assured tone. He slices off Michael Palin through code-exchanging in light of the fact that he needs to be increasingly hostile and assaulting, which is demonstrated by what he says, â€Å"Popper’s on about falsifiability†¦Ã¢â‚¬  This shows John Cleese is entirely learned and since this is an announcement, which can't be contended against, John Cleese starts to join and impact the crowd that he is correct and that what the resistance is stating is erroneous. Likewise, John Cleese delays now and again during his little discourse, â€Å"I was also†¦they were composed in† which shows how John Cleese attempts to impact the resistance that they are incorrect. The impact of delaying joins with theâ audience and the restriction as it demonstrates where a point has been made and furthermore gives them an opportunity to process it. Then again, the Church likewise attempts to impact others with their language. â€Å"†¦much too tenth-rate† here, Malcolm Muggeridge continues rehashing that the film is awful however doesn't clarify why. This is a case of where somebody has endeavored however fizzled at affecting the crowd. Despite the fact that he gets a reaction from the crowd, it is very dissimilar in light of the fact that the crowd moan as they comprehend that Malcolm has thought about this literally and has started to arrange affronts at Monty Python. In addition, this is additionally demonstrated here, â€Å"it’s very conceivable that they may as a bit of social history† we can comprehend that Malcolm is neglecting to impact the crowd that he is correct in light of the fact that he is socially distant. By then, Monty Python was famous and Malcolm is recommending that somebody will just haphazardly go over it since he wouldn't like to acknowledge the way that Monty Python has listener support because of their ubiquity. Also, all through the discussion, there is a fight for who is the most prevailing. John Cleese is most prevailing on the grounds that in addition to the fact that he speaks the most he, wins over the crowd as he gets listener support, â€Å"Not an interesting structure, really†¦Ã¢â‚¬  Moreover, John Cleese’s focuses likewise end up being a lot to deal with by the resistance as they neglect to respond to the inquiries he pose, â€Å"Is there anything that would? Here, Malcolm Muggeridge neglects to answer to this inquiry, rather he starts saying that the film is simply awful. Additionally, he is most predominant in light of the fact that he steps the discussion to the following level, scrutinizing the presence of a religion that has been accepted by individuals for more than 2000 years, â€Å"†¦Gospels were written in, that they don’t even realize who kept in touch with them, and they’re not by any means sure what urban areas they were written in. † This presents strength since he is scrutinizing an entire religion on whether Christianity is 100% precise. It isn't just John Cleese’s language yet his paralinguistic includes likewise help him not exclusively to impact the restriction and the crowd yet additionally Michael Palin; â€Å"†¦an thought that is humming around so quick that not other†¦Ã¢â‚¬  Normally, John Cleese’s paralinguistic highlights are comprehensive (e. g. fastening of hands), yet now he utilizes paralinguistic includes as though showing Michael Palin and these paralinguistic highlights help to unite with the crowd as John Cleeseâ has now got the complete consideration of everybody. Then again, despite the fact that Malcolm Muggeridge says a great deal, he is one of minimal predominant as what he says is very useless as it doesn't accomplish anything, â€Å"†¦much too tenth-rate for that † here, Malcolm says that the film is terrible yet neglects to address an inquiry presented by John Cleese which shows how he is reluctant, realizing that he has lost the discussion however wouldn't like to acknowledge it. Malcolm makes kill remarks attempting to cause the crowd to disregard what John Cleese says, be that as it may, this doesn't work out. All things considered, Monty Python won the discussion and subsequently, to make dissemination, Mervyn Stockwood offers a little remark to end the discussion off with a chuckle, â€Å"I used to go to Clifton College to lecture all the time when you were there. † This discussion shows how Monty Python target and challenge individuals with extraordinary power, just so they, before the end, can cast them in an awful light.

Sunday, July 5, 2020

9 Important US History Topics to Learn for APUSH

With so many US history topics covered in APUSH, it’s hard to know where to focus your studies. This guide is intended to give you a place to start. Here is one important US history topic from each of the 9 APUSH periods. 1. Europeans vs. Native Americans Period 1 is all about early European exploration of the New World and the contact they made with Native Americans once they got there. You’ll want to be especially familiar with: the devastating effect that European diseases had on native populations how the Spanish used the encomienda system to oppress the natives for their own economic gain how the exchange of goods affected both North America and Europe (e.g., the introduction of horses to North America and the introduction of corn to Europe) 2. Characteristics of the 13 British Colonies Period 2 narrows in on the British colonization of North America and gives us our first introduction to the thirteen colonies that would eventually become the United States. A key topic to understand in this period is the regional differences between the Southern, Middle Atlantic, and New England colonies. For a thorough overview of the regions (including a handy summary chart), check out this site from Humboldt State University. 3. Causes of the Revolutionary War Period 3 centers on the causes, events, and aftermath of the American Revolution. You’ll want to focus especially on the causes, particularly the events from 1763 (the end of so-called salutary neglect) to 1776. Be sure you’re familiar with these important underlying themes: development of a separate American identity in the colonies influence of Enlightenment ideas (especially John Locke) conflict over virtual vs. direct representation 4. Westward Expansion Period 4 covers 1800 to 1844. This is when America really starts to grow and try to find its place in the world. One key topic from this period is westward expansion. You’ll want to be familiar with: the philosophy of Manifest Destiny and its impact the various means by which the US expanded westward (e.g., purchase, war) how the US dealt with Native Americans as it encroached further onto their lands how the growth of transportation (especially railroads) and industry was both a cause and an effect of westward movement 5. Causes of the Civil War Period 5 covers everything surrounding the Civil War. As you study, you’ll want to spend less time on the details of the â€Å"main event† (the war itself) and more time on the build-up to the war. Make sure you have a solid grasp of: differences between the North, South, and West and how each fought for their interests (sectionalism) the conflict over slavery (including defense of the â€Å"peculiar institution† vs. the rise of the abolitionist movement) the struggle over federal government representation (especially Senate seats) for slave states and free states, and how that played out in the western territories (e.g., Missouri Compromise, Compromise of 1850, Kansas-Nebraska Act, etc.) 6. Industrialization Period 6 gives us the post-Reconstruction era, sometimes known as the Gilded Age. This was the age of the rise of big business. You’ll want to be familiar with: the growth of American industry, especially in steel, oil, and railways major players in the industrial world (especially the so-called â€Å"robber barons†) the role of immigrants in the labor force the downside of industrialization, including poor working conditions and unsanitary urban living environments 7. The Interwar Period Period 7 contains both World War I and World War II, so it’s easy to get caught up in those huge events and forget about everything else. Here is your friendly reminder to focus on what was going on domestically during the period, especially in the interwar period. Here are some highlights of the 1920s and 1930s that you’ll want to remember as you study: industrial growth, prosperity, the rise of credit, a lack of regulation, and rampant consumerism in the Roaring 20s the Great Depression and efforts to remedy it (especially the New Deal) the struggle between isolation and international involvement immigration and the backlash against immigrants and minorities (e.g., rise of the KKK, Red Scare) continued racial tensions (e.g., segregation, disenfranchisement) women’s rights (suffrage achievement nationwide in 1920) 8. Social Movements In period 8, the foreign policy focus is, of course, the Cold War. At home, however, the US was going through a LOT of changes in this period. Make sure you’re familiar with these social changes: Civil Rights Movement Women’s Rights Movement student-led protests against the government War on Poverty (Johnson’s Great Society) rise of suburbs and mass culture 9. The Post-Cold War World Period 9 takes us from 1980 to the present. The 1980s and early 1990s saw the Cold War draw to a close and the world realign. Be sure to study globalization and the foreign policy shift to focus on the Middle East, especially in the â€Å"War on Terror† following September 11, 2001.

Tuesday, May 19, 2020

Cannabinoid As A Treatment For Social Anxiety Disorder - Free Essay Example

Sample details Pages: 8 Words: 2441 Downloads: 8 Date added: 2019/04/01 Category Psychology Essay Level High school Tags: Anxiety Essay Did you like this example? 2Over the past few years, marijuana and its many compounds have been becoming increasing popular around the world. One compound in particular, cannabinoid (CBD), a non-psychoactive compound of tetrahydrocannabinol (THC), has been of great interest as a potential treatment for numerous medical diseases. As recent as 2018, cannabinoid has been approved as an alternative anticonvulsant medications for treatment refractory seizures (Epidiolex, 2018). The success of using this drug as a treatment for this neurological disorder has lead to further research of this product for other symptoms and disorders from pain and nausea/vomiting, to a variety of psychiatric disorders. New research on CBD being an effective treatment for anxiety, particularly social anxiety disorder (SAD) is promising. SAD is characterized by excessive fears of scrutiny, embarrassment, and humiliation in social or performance situations, leading to significant distress or impairment in functioning (American Psychiatric Association, 2018). This condition is estimated to affect between 3-7% of the US adult population and, if untreated, can be associated with the development of major depression, substance abuse, along with extensive functional impairment, and reduced quality of life (Ruscio et al., 2008). Don’t waste time! Our writers will create an original "Cannabinoid As A Treatment For Social Anxiety Disorder" essay for you Create order As the popularity of this drug increases, more patients may be tempted to try this easily accessible supplement for their mental health problems. For future medical providers, who will no doubt receive inquiries for this drug, it would be good to be able to reply with scientific, evidence-based responsed. In this literature review, we will discuss the latest research surrounding CBD and develop a better understanding if CBD is as a safe and effective for treating adults age 18-65 with SAD. These next few studies examine the effect of CBD on experimentally induced anxiety. As SAD anxiety is often acute and induced by stressful social situations, acute anxiety induced by experimental situations is a good equivalent. These studies all measure CBDs effect on acute anxiety induced from stressful experimental situations. This first study investigates the action of CBD on participants undergoing a stress-inducing neuroimaging procedure. The single-photon emission computed tomography, or SPECT, measures the limbic and paralimbic brain, areas that are known to be associated with anxiety (Crippa et al., 2011). In a double-blind placebo, 10 participants diagnosed SAD were given either CBD or a placebo and then underwent the procedure. In the next session, the same procedure was performed, with patients who received CBD in the first trial now receiving a placebo and vice versa. Participants anxiety was also measured throughout using subjective questionnaires. The results of the trials showed a significant decrease in participants subjective anxiety (p0.001) and reduced regional cerebral blood flow (rCBF) in overlapping but distinct limbic and paralimbic areas (p†°Ã¢â‚¬ °0.001). Because the rCBF was overlapping and not exactly consistent with areas associated with anxiety, this study failed to find a correlation between the anxiolytic effects of CBD on neuroimaging. However, this study did demonstrate a reduction in presumed anticipatory anxiety associated with undergoing SPECT procedures. The next study examined the effects of CBD on healthy participants and participants with SAD undergoing a simulated public speaking test (SPST) (Bergamaschi et al., 2011). A previous 2008 study found that during a SPST, participants with SAD have higher anxiety levels, greater cognitive impairment, discomfort, and decreased alertness compared with the control group (Crippa et al.). During the study, participant with SAD or healthy controls received either CBD or a placebo in a double-blind randomized design. The participants then performed a SPST. Subjective and physiological measurements of anxiety were measured throughout the study Based on the measurements of subjective anxiety, the group with SAD who did not receive CBD had higher anxiety, cognitive impairment, discomfort, and diminished alert levels than the SAD CBD group. The study concluded that in participants with SAD, CBD reduced subjective anxiety symptoms resulting in a similar response to the SPST as healthy controls, yet no significant differences were noted among the physiological measures of anxiety. In another 2013 study, a Pavlovian fear and learning mechanism was used to induce conditioned fear on participants by shocking them with a colored box and electric shocks ((Das et al., 2013). This study sought to examine CBD on Pavlovian fear and learning mechanisms as they are an important component to anxiety disorders (Watson Rayner, 1920). Once participants established fear of the box, the researchers tested how long it took to un-condition that fear or for that fear to go through extinction. The participants were divided into three groups, one group receiving CBD before fear extinction, one receiving CBD after fear extinction, and one not receiving CBD at all. Throughout the study, anxiety, current mood, and physical symptoms were assessed with various subjective questionnaires, skin conductance response, and shock expectancy following extinction. The results of this study found that CBD had no acute effects on fear extinction. However, CBD given to the post-extinction group enhanced consolidation of extinction as measured by shock expectancy. The study also found that CBD given either pre or post-extinction reduced restoration of autonomic contextual responding. These preliminary findings show promising evidence that CBD may be an effective adjunct to extinction-based therapies for anxiety disorders. Now that we have examined studies that that show a positive correlation between CBD and reduced anxiety in SAD and healthy volunteers, we will now look at some studies that come to different conclusions. Some studies have concluded that CBD has no effect on baseline anxiety in healthy volunteers. A 2012, double blind, crossover, placebo-controlled trial looked at the effects CBD compared to THC and a placebo on 16 healt hy volunteers (Martin-Santos et al.). The drugs and placebo were administered in consecutive sessions in a one-month interval. Symptoms of anxiety were measured using physiological measurements and symptoms ratings at the 1, 2, and 3-hour intervals. The data was analyzed and the researches concluded that there were no differences between the CBD and placebo on any symptomatic or physiological variables. However, unlike previous studies discussed, participants were not placed in simulated anxiety-inducing situations. Though the study may have found no effect of CBD on baseline anxiety, had these volunteers been placed in acutely stressful situations, maybe CBD would have had an anxiolytic effect. Another more recent study found similar results. This study was looking into the effects of THC and CBD, both alone and combined on subjects ability to process emotional affects deficits in which are characteristic of mood disorders like depression or anxiety (Hindocha et al. 2015). Partici pants involved varied in at-home cannabis use and had various types of schizotypy. In a 4-way, double-blind, placebo-controlled crossover design, participants inhaled either THC, CBD, both THC and CBD, or a placebo and completed an emotional facial affect recognition task and a visual analogue scale of how stoned participants felt, was completed. The study concluded that CBD did not influence feelings of being stoned and improved recognition of emotional facial affects and weakens the impairment induced by THC. However, the study also investigated the correlation between self-report measures with performance on the emotional processing task across CBD administration, to see whether baseline psychological wellbeing was associated with performance accuracy. However, no statistically significant correlation was found, with ps 0.05 after analysis. This demonstrates an opposite correlation from the earlier study where CBD improved cognitive impairment, discomfort, and diminished alert levels all associated with diminished performance accuracy (Bergamaschi et al., 2011). Again, CBDs effect was only tested on these participants baseline anxiety, and not its effect on participants in anxiety augmented scenarios. Though CBD may not show as promising evidence as a treatment for long-term anxiety like generalize anxiety disorder, it does show efficacy as treatment for acute anxiety like in social anxiety disorder. Various studies have established clinical evidence for CBDs efficacy for SAD. We will now examine how CBD compares to other treatments for SAD. Current medical therapies for this disorder include drugs like selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), monoamine oxidase inhibitors (MAOI), and benzodiazepines (Stein, 2018). These medications are not without side effects and adverse health outcomes. Also, unlike CBD, in the case of many of these medications (ex: SSRIs) a patient may have to take the medication for several weeks before they feel the effect of the medication (Taylor et al. 2006). A systemic review analyzed recent studies on CBD, both preclinical animal studies and clinical studies on humans (Blessing et al., 2015). The study noted that there was substantial evidence that CBD showed comparable efficacy to ipsapirone (a 5-HT1AR agonist) or diazepam (a benzodiazepine), other treatments for SAD. The downside to all of these studies include small sample size, sample bias, and lack of serum CBD levels to correlate with subjective and physiologic measures of anxiety. Though there are many pre-clinical animal studies confirming its effectiveness for treating many mental health disorders, there are few clinical trials that have concluded its efficacy and many of which demonstrate mixed results (Blessing et. al., 2015). Unfortunately with todays regulatory and sociopolitical climate, research on marijuana and its many components is significantly limited (Farach et al., 2012). Until it becomes easier for research on CBD to be performed, including recruiting large enough sample sizes to sufficiently identify comprehensive treatment effects, there may not be adequate evidence to support CBD as an effective treatment for anxiety. Though it may be hard in the current climate to definitely prove that CBD is effective for SAD, CBD is still a product that is currently available over the counter to everyone. For people who have heard about the proposed power of the drug and want to try it, are there any risks in taking it? In this next portion of the paper, the safety profile and side effects of CBD will be discussed. A 2011 literature review examines the safety and side effect profile of CBD and concluded that based on recent advances in CBD administration, controlled CBD may be safe in humans and animals (Bergamaschi et al.). The study looked at the effect of CBD on in vitro studies animals find CBD to have no effect on embryonic development, increased food intake, development of catalepsy, and no effect on motor changes.  Additionally, in animal models, the review found that CBD had no effect on many physiological parameters including blood pressure, heart rate, body temperature, glucose levels and did not induce ataxia, tremors, vomiting, and many other negative physical effects. In human studies, even at a wide range of doses, CBD was not found to cause adverse side effects in acute or chronic studies. CBD does not interfere with heart rate, blood pressure, or performance in a verbal paired associated learning test (Zuardi et al., 1982). Chronic studies even found it may be an effective treatment for refractory cases of schizophrenia, bipolar affective disorder, Parkinsons disease, and cannabis addiction (Bergamaschi et al.). The systemic review did note that in several in vitro and in vivo studies CBD had to the potential to interact with hepatic drug metabolism, decreased capacity of fertilization, and decrease activity of some drug transporters. The review concluded with a statement that CBD, even at relatively high doses and with chronic use, is well tolerated in humans. The review does admit that further research is needed to determine accuracy of the reported side effects and that constant monitoring of the drug is required when used for clinical use. As previously mentioned, CBD is FDA approved as prescription as adjuvant therapy for seizure disorder (Epidiolex, 2018). Clinical trials of the drug found that potential side effects of this drug include central nervous system depression (drowsiness, lethargy, sedation, etc.), skin rash, weight loss, decreased appetite, anemia, increase serum alanine aminotransferase and transaminases, infection, and asthenia. Though the only contraindication to this medication involves a hypersensitivity reaction to CBD, there are other warnings that patients must be aware of before taking this medication. For example, CBD may cause CNS depression, which may be hazardous if driving or operating heavy machinery. Also, the increase in liver transaminases have caused a few patients to become hospitalized. Though patients who are most often have a significant increase in hepatic transaminases have a high baseline transaminase, use other seizure medication that are hepatotoxic, and take a high dose of CB D. Though there is evidence that CBD in general has a good safety profile, people should still be cautious when taking it, even when the CBD they are taking is prescribed from a doctor and FDA approved. Unfortunately, the popularity of this miracle cure is not affected by the lack of solid scientific confirmation and largely unknown safety profile. There are abundant of producers and sellers of CBD that are active in the market distributing CBD as a supplement without regulation (Hazekamp, 2018). There are growing concerns over the legality, quality, and safety of this new over the counter drug. A 2017 study investigated the content of 46 different samples of CBD (Hazekamp). The samples came from various sources, some home-made and some were purchased from an online webstore, some had labels describing the contents, some did not. The researchers then analyzed the components of the CBD oil and compared it, when possible, to the contents advertised on the label. The study found that not only did the CBD content widely vary from the advertised about, 15% of the samples contained no CBD at all while 57% of the samples also contained 1% THC. Though many of the samples, analyzed advertised a high THC content, the researchers where unclear whether CBD consumers were always aware of this. Additionally, the study found there was a high level of non-decarboxylated cannabinoids, a precursor to CBD, in many samples. These non-carboxylated cannabinoids are converted to CBD after proper heating, yet research on the efficacy and safety of these precursors is significantly limited. This is not an isolated stud, many other studies have developed similar conclusions about questionable CBD content of many products on the market. Since 2015, the FDA has issued an annual warning letter about CBD drugs on the market that do not contain the levels of CBD they claimed (2015/2016 warning letters and test results for cannabidiol-related products). CBD therefore may be an effective therapy for SAD, if CBD truly does have the assumed anxiolytic properties confirmed in animal trials and the few clinical trials. If the side effect profile of the drug is indeed safe, it may be a good alternative to current medications used for this drug. However, current clinical evidence for this medication is mixed, and while many case reports and animal studies show positive evidence of CBDs efficacy, providers should still be cautious recommending CBD to patients.  Additionally, CBD is not without side effects and risks even when the product is FDA approved. Current products available to consumers have unknown CBD content that is not subjected to any regulatory body. Before this new medication can be recommended to patients for SAD, more research must be done.

Wednesday, May 6, 2020

My Career As A Nurse - 1890 Words

This world offers so many career opportunities, from being an elementary teacher to a yoga instructor to a cardiologist. The job variety is endless, and anyone has the potential at becoming a professional in the career of their dreams. I’ve always known I wanted to go college, and now I know I want to become a nurse anesthetist. Since I was little, I haven’t always dreamed of becoming a nurse anesthetist. When I was younger if someone would ask me what I wanted to be when I got older, I would say I wanted to be a singer, a teacher, or a chef, and that answer would change on a regular basis. Even recently now I’ve changed my future career from being a physical therapist to a psychiatrist to a registered nurse. A registered nurse spends an average day in the hospital assisting and managing patients with medicine, documenting information, and communicating with supervisors, peers, and subordinates. A registered nurse that specializes in anesthesia, which is a nurse anesthetist, will always be doing specific tasks such as: administering anesthesia to patients before and during surgery and they care for and monitor patients before, during, and after surgery. I would love to become a nurse anesthetist, because I want to be able to help care for others and I want to be in an environment where I am helping patients recover and helping with pain. After doing research and asking many questions, I’ve become dead set on becoming a nurse anesthetist. In the medical field, aShow MoreRelatedMy Career As A Nurse939 Words   |  4 Pagesdoing in my nursing career in the upcoming five years. I have many hopes and dreams I hope to fulfill in my future career as a nurse. I want to be thriving and making the differences I am deeply committed to. I want to establish strong relationships with not only my patients, but my peers as well. I want to be exceptionally skillful in my field to the point of educating others and lending a helping hand any where possible. More than anything I want to be extremely effective and efficient in my careerRead MoreMy Career As A Nurse Essay1153 Words   |  5 PagesThroughout our lives, we will encounter different people that will leave imprints in our career. Some of them will lift you up and some will bring you down. The person that I am sharing with you is someone that inspired me to forgo my pursue of my Master’s degree. The reason I picked this person is because she isn’t only a mentor, but someone that I look up to and rely on when I have questions. As a young registered nurse, we need someone to lean on especially when working the night shifts. ResourcesRead MoreMy Career As A Nurse1494 Words   |  6 PagesMy Nursing Career Not everyone has the calling to be a nurse but I am one of the lucky ones to be called to this wonderful profession. Being a nurse has its ups and downs like any other profession, but being able to make a difference in someone’s life is an absolute blessing. It took me a long time to reach my ultimate goal of becoming a registered nurse but I made it with a lot of help from my family. Life stories Ever since I was in high school I had wanted to be a nurse. I took two yearsRead MoreMy Career As A Nurse Practitioner1356 Words   |  6 Pagesinterested in starting my career as a registered nurse either in the emergency department (ED) or in the intensive care unit (ICU). I know the thought of starting out in ED or ICU can be intimidating for newly graduated nurses, but I want to establish a strong foundation in nursing and work with complex cases even at the start of my career. I believe this will be tough in the beginning but will eventually open up so many other opportunities for me down the road. I am aspiring to be a Nurse Practitioner asRead MoreMy Career As A Nurse Practitioner Essay980 Words   |  4 Pages Ive always wanted a rewarding career that revolved around helping people. I want to pursue a career as a nurse practitioner. I am not sure on what specialty I want. So given a assignment in my Introduction Health Sciences class where I have to shadow a nurse pract itioner, it gives me the opportunity to explore a specialty and see what it really is like in their typical work day. An advanced practice registered nurse, by the name of Mary Carlson at Parkland Medical Center was willing to let me shadowRead MoreMy Career Path For A Nurse1388 Words   |  6 Pagesalways want to be a nurse. Nursing is a fairly new career path for me, and while I love it now, I have had several things that I could turn into career fields. If I was asked what I wanted to be when I grew up when I was five, I would have told you that I wanted to move to Japan and make video games. 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Comparison of Web Services Free Samples †MyAssignmenthelp.com

Question: Discuss about the Comparison of Web Services. Answer: Comparison of Web Services for Amazon, Microsoft Azure and Google The first comparison for storage used in Amazon Web Services, Google, and Microsoft Azure. Amazon offers Elastic Block Storage (EBS), which is block storage. It uses three types of disks with volumes ranging from 1TB to 16TB for magnetic disks and SSD disks respectively. The information of Amazon is put away in a solitary accessibility zone. Their object storage service is simple storage service (s3). On the other hand, Microsoft Azure provides Blobs for storage. Azures block storage service is called Disks and Page Blobs. They provide for both premium and magnetic disks with volumes of only up to 1TB. Their storage service is offered on four levels where they offer redundancy to provide for high availability and durability. Google block storage organization is a unit with options for either SSD or magnetic volumes. Ephemerical disks also form the block storage whose configurations are complete. Google partitioned into three levels known as durable, standard and Reduced Availability. With Google, data streaming is fast. Comparing networking. The networking aspect of cloud computing is met with capabilities by all the three companies such as domain name system (DNS), Load balancing together with virtual private networks. Such proficiencies guarantee reliable and robust networking abilities (Del Alba, 2016). They enable users to create their networks in the cloud. All the three companies; Amazon, Microsoft Azure, and Google, permit users to route their networks, create subnets and even assign IP addresses. Drawing comparison in Virtual Machine Management. Google Cloud Platform has various tools to simplify management of information systems. Cloud Deployment Manager makes it possible to postulate necessary resources needed by a user declaratively. Additionally, there are templates that allow systematic deployment of models (Del Alba, 2016). Amazon Web Service, on the other hand, makes it possible for system admins to generate resources, collect and make them, then update them in an orderly fashion. Microsoft Azure enables easy creation of application plus the ability to edit strictures (Stackify, 2017). Comparing IP Address Allocation. All the three companies; Amazon, Microsoft Azure and Google, allow for dynamic host configuration (DHCP) where there is automatic assigning of IP addresses in the cloud. However, Amazon added a new IP address capability where users can assign IP addresses of their choice in their virtual private cloud. This is because DHCP consumes time to effect compared to static. (Stackify, 2017). Microsoft Azure has admitted running out of IPv4 addresses in the US and is now using IPv6 for Azure virtual machines in various regions like Brazil South, Central US, and West Europe. Amazon Web Services and Google Cloud Platform also support IPv6. Redundancy and backup for Amazon Web Services, Google, and Microsoft Azure. Amazon Web Services provides for block storage volumes, which are replicated within the period it is available to ensure there is no data loss, hence providing for increased durability and high redundancy. In time snapshots of the block, volumes are taken which acts as a backup (Stackify, 2017). There is a continuous replication of Data in the Microsoft Azure storage account. This makes sure there is no data loss in an event where there is hardware damage on the primary device. Azure provides several redundancy options including Geo-redundant storage (GRS), local redundant storage (LRS), read access- Geo-redundant storage (RA-GRS) (Del Alba, 2016). Google provides for seamless redundancy options that are ever available to ensure there is no data loss. Google also provides for regular data backup (Stackify, 2017). List of Distributions of Amazon Web Services, Google, and Microsoft Azure Amazon Web Services: CentOS, SUSE, Debian, Kali Linux, Red Hat, Ubuntu. Google Cloud Platform Distributions for Google Cloud platform include CentOS, CoreOS, Debian, Red Hat, Ubuntu, SUSE, SLES. Microsoft Azure Distributions of Microsoft Azure: Debian, CentOS, SUSE, Red Hat, Ubuntu References Del Alba, L. (2016).A Side-by-Side Comparison of AWS, Google Cloud and Azure SitePoint. [online] SitePoint. Available at: https://www.sitepoint.com/a-side-by-side- comparison-of-aws-google-cloud-and-azure/ [Accessed 23 Sep. 2017]. Stackify. (2017).Azure vs AWS vs Google Cloud: Compare Services Features. [online] Available at: https://stackify.com/microsoft-azure-vs-amazon-web-services-vs- google-compute-comparison/ [Accessed 23 Sep. 2017].

Tuesday, April 21, 2020

Ashitaba Essay Example

Ashitaba Paper Hyperlipidemia is the elevation of fasting blood triglyceride and cholesterol concentrations. This condition may be inherited or may be a consequence of another disorder such as hypothyroidism, alcohol dependence, kidney failure, and diabetes mellitus and can also raise the risk for heart disease, heart attack, and stroke. It is not an illness itself but merely a condition that can be linked to serious diseases and can be prevented by lifestyle modification and medications. Cases of hyperlipidemia in the Philippines increase spontaneously in the recent years. Current advances and developments in technology made it more convenient and easy for researchers to identify and analyze the therapeutic properties of a plant material that can be valuable in modern medicine. Several articles had cited plants that can help lower lipid level in the blood. Gynura nepalensis DC (Ashitaba) is one of them. Gynura nepalensis DC is the ashitaba grown in the Philippines. It is also called Gynura procumbens and Gynura acutifolia. Ashitaba (Angelica keiskei Kodzumi) is the ashitaba which originated in the Island of Hachijo, Japan. Both ashitaba (Gynura nepalensis and Angelica keiskei Kodzumi) have been claimed to be anti-oxidant, anti-cancer, anti-aging, anti-inflammatory, antihypertensive, and antidiabetic. Furthermore, it can treat disorders like cough, asthma, kidney stones, urinary tract bleeding, hepatitis, gall bladder stones, hemorrhoids, constipation, diarrhea, vomiting, blood poisoning, septicemia, fertility problems, external wounds, skin allergy, rheumatism, high cholesterol levels, high-low blood pressure, and diabetes. It also suppresses growth of cancer cells, aids in more balanced blood cells and helps in the recovery of bone injuries. (Ursulom, 2013) Statement of the Problem The study aims to determine the effectiveness of crude ethanolic extract that will be obtained in Gynura nepalensis DC (ashitaba) leaves and stems for the treatment of hyperlipidemic mice. Specifically, the study will be seeking answers from the following objectives: Conduct phytochemical screening of the crude ethanolic extract. Assess the extent of lipid lowering activity of the crude ethanolic extract in different concentrations. We will write a custom essay sample on Ashitaba specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on Ashitaba specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on Ashitaba specifically for you FOR ONLY $16.38 $13.9/page Hire Writer Compare the effectiveness of the crude ethanolic extract with the standard drug simvastatin (Zocor ®). Hypothesis Ho:The crude ethanolic extract at 5mg/kg, 10mg/kg, and 20mg/kg concentrations does not elicit lipid lowering activity when compared with the standard drug, Simvastatin (Zocor ®). Ha:The crude ethanolic extract at 5mg/kg, 10mg/kg, and 20mg/kg concentrations elicit lipid lowering activity when compared with the standard drug, Simvastatin (Zocor ®). Significance of the Study This study will be a useful tool in dealing with the concerns regarding the increasing prevalence of hyperlipidemia in the country. The further determination of the active constituents and therapeutic properties of ashitaba plant can be beneficial to the medical field. This can also be a basis for a more advance analysis and identification of the pharmaceutical material that the plant bears. Since ashitaba plant is becoming well known in our country, this study can be a useful reference to the future researchers. It can encourage and motivate them to further expand the study into a wider point of view by not confining the study in the effects of the leaves and stems of the plant extract in the reduction of lipid level in mice. Scope and Delimitations of the Study The study will be confined on the effects of ashitaba crude ethanolic extract in high lipid level in mice. Extracts are prepared in 3 different strengths 5 mg/kg, 10mg/kg, and 20 mg/kg, for the comparison and evaluation of the effect in different concentrations. Lipid lowering activity will be performed; simvastatin (Zocor ®) will serve as the positive control, the different concentrations as the experimental control, and the ethanolic base as the placebo. Along with this, complete blood count will be assessed to support the data of lipid lowering activity.